1,1'-Carbonyldiimidazole → 1-Cyclopropyl-1,3-dihydroimidazo[4,5-c]pyridine-2-one
反応式
C1N=CN([C:6](N2C=NC=C2)=[O:7])C=1.[CH:13]1([NH:16][C:17]2[CH:22]=[CH:21][N:20]=[CH:19][C:18]=2[NH2:23])[CH2:15][CH2:14]1>CC#N>[CH:13]1([N:16]2[C:17]3[CH:22]=[CH:21][N:20]=[CH:19][C:18]=3[NH:23][C:6]2=[O:7])[CH2:15][CH2:14]1参加物
4
反応条件
- 温度
- 10 °C
実験手順
CDI (CAS 530-62-1) (151.8 g, 936 mmol) was added to a solution of the intermediate 5-c (133 g, 891.4 mmol) in CH3CN (1800 mL) at 0° C. The reaction was allowed to warm to 10° C. and stirred for 1 hour. The solid was collected by filtration, then washed with CH3CN (200 mL) to afford compound 5-d as a white powder (101 g, 65%).
後処理
- filtrationThe solid was collected by filtration
- washwashed with CH3CN (200 mL)
- customto afford compound 5-d as a white powder (101 g, 65%)
出典と根拠
- ORDレコード
- ord-b2e1507672b34560aeead35047c16c37
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09339494B2
反応ノート
読み込み中…