N-bromobutanimide → 2-Amino-5-bromo-4-methoxybenzaldehyde

HRID 524072

反応式

HRID 524072 の反応式
[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[Br:12]N1C(=O)CCC1=O>ClCCl>[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([Br:12])=[CH:6][C:3]=1[CH:4]=[O:5]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 3235032-Amino-4-methoxybenzaldehyde

生成物 1

HCID 593252582-Amino-5-bromo-4-methoxybenzaldehyde収率 56%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 2-amino-4-methoxybenzaldehyde (6 g, 39.7 mmol) in dichloromethane (100 mL) was added N-bromosuccinimide (7 g, 39.7 mmol). LCMS monitored the reaction until the starting material consumed completely. The reaction mixture was diluted with dichloromethane and water. The separated organic layer was dried sodium sulfate, filtered and concentrated to give the title compound (5 g, 56%) as a yellow solid. MS (ES+) C8H8BrNO2 requires: 229, 231. found: 230, 232 [M+H]+.

後処理

  1. customthe reaction until the starting material
  2. customconsumed completely
  3. additionThe reaction mixture was diluted with dichloromethane and water
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-155398206c3b4298ade26f276c7a08a2
出典データセット
uspto-grants-2016_05
特許番号
US09340514B2

関連ノート

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