Ethylene Oxide → 3-Phenoxy-1,2-propanediol

HRID 5244

反応式

HRID 5244 の反応式
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:2]1[O:4][CH2:3]1.C1C2NC3C(=CC=CC=3)SC=2C=CC=1.[O:26]1CC1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>[Br-].C([N+](CCC)(CCC)CCC)CC.C1(C)C=CC=CC=1>[O:5]([CH2:1][CH:2]([OH:4])[CH2:3][OH:26])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

7

反応物 4

HCID 6354Ethylene OxideHCID 7108PhenothiazineHCID 31217Phenyl glycidyl etherHCID 521998p-Toluenesulfonic acid monohydrate

生成物 1

HCID 108573-Phenoxy-1,2-propanediol

試薬・触媒・溶媒 2

HCID 74745Tetrapropylammonium bromide触媒HCID 1140Toluene溶媒2 回

実験手順

A solution of 150.2 g. phenyl glycidyl ether (1.0 eq.), 200.0 g. AOnPA (1.15 eq., of Example 1), 200.0 g. toluene, 4.0 g. tetrapropylammonium bromide (0.015 eq.), and 1.0 g. phenothiazine was heated at reflux for 6.0 hours. Conversion, measured by residual oxirane titer, was ca. 93%. Upon cooling, the reactor was charged with 186.0 g. of the AOnPA (1.07 eq.), 150.0 g. toluene, and 10.0 g. p-toluenesulfonic acid monohydrate (0.05 eq.). The mixture was again heated at reflux. After 6.0 hrs., conversion was 90%. The product was extracted with ether and purified by washing. It had an acrylate titer of 3.8 meq./g. (theory: 4.17 meq./g.) and Brookfield viscosity of 230 centipoise at 25° C.

後処理

  1. temperatureat reflux for 6.0 hours
  2. temperatureUpon cooling
  3. additionthe reactor was charged with 186.0 g
  4. temperatureThe mixture was again heated
  5. temperatureat reflux
  6. extractionThe product was extracted with ether
  7. custompurified
  8. washby washing
  9. customat 25° C.

出典と根拠

ORDレコード
ord-167fda6db42f40c2b04d4c02c0deb86d
出典データセット
uspto-grants-1993_09
特許番号
US05243069

関連ノート

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