Hydrazine hydrate (1:1) → 6-[(3-Methyl-1,3-dihydro-2-benzofuran-4-yl)oxy]-3-pyridinamine

In a 50 ml round-bottomed flask 2-[(3-methyl-1,3-dihydro-2-benzofuran-4-yl)oxy]-5-nitropyridine (Intermediate 99, 38.3 mg) was dissolved in ethanol (10 ml) to give a pale yellow solution. Pd/C (14.22 mg, 0.013 mmol) and hydrazine hydrate (0.026 ml, 0.267 mmol) were added. The reaction mixture was stirred at 90° C. After 45 minutes, the reaction mixture was filtered and the organic phase was evaporated under vacuum to afford the title compound (32 mg).

1. customto give a pale yellow solution
2. filtrationthe reaction mixture was filtered
3. customthe organic phase was evaporated under vacuum

ORDレコード

ord-9b6725387e184a65b82a608506962a9c

出典データセット

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09346790B2