Flurbiprofen → 2-Hydroxyethyl Methacrylate

反応式

C[C@H:2](NC([C@@H](NC([C@@H](NC(N[C@H](C(O)=O)CC(C)C)=O)[C@H]1NC(=N)NCC1)=O)CCC(N)=O)=O)[CH:3]=[O:4].[CH3:37][CH:38]([C:52]([OH:54])=[O:53])[C:39]1C=CC(C2C=CC=CC=2)=C(F)C=1.C[C@H]1[C@](O)(C(COP([O-])(O)=O)=O)[C@]2(C)[C@H]([C@H]3[C@](F)([C@@H](O)C2)[C@]2(C)C(=CC(C=C2)=O)CC3)C1.[Na+].C1[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@@H](O)[C@@H]1N.OS(O)(=O)=O>>[C:52]([O:54][CH2:2][CH2:3][OH:4])(=[O:53])[C:38]([CH3:37])=[CH2:39]

参加物

反応物 4

HCID 3394Flurbiprofen

HCID 197162Neomycin Sulfate

HCID 23667621Dexamethasone 21-(sodium hydrogen phosphate)

HCID 178418625HCID 178418625、化合物

生成物 1

HCID 133602-Hydroxyethyl Methacrylate

実験手順

A mixture was prepared by combining aprotinin 1 g.; elastatinal 0.1 g.; flurbiprofen 0.1 g.; dexamethasone sodium phosphate 0.1 g.; neomycin sulfate; and physiological saline up to 100 g. A contact lens form the crosslinked polymer of 2-hydroxyethyl methacrylate (38 percent by weight of equilibrium water) was swelled in the given solution for 24 hours. The contact lens was used for the treatment of nonhealing corneal erosions. Within a week after application the reepithalization was sped up. Extraordinary results were attained after severe etching and burning of the anterior segment of the eye. The intraocular inflammation did not develop, the cornea did not exhibit ulceration and healed with a scar to place within a month. The transparency recovered in the periphery of the cornea.