Lithium Hydroxide → N-[(5-tert-butoxycarbonylthiophen-2-yl)methyl]-N-methyl-L-leucine lithium salt

HRID 529216ノート

反応式

HRID 529216 の反応式
C[O:2][C:3](=[O:24])[C@H:4]([CH2:20][CH:21]([CH3:23])[CH3:22])[N:5]([CH2:7][C:8]1[S:9][C:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[CH:11][CH:12]=1)[CH3:6].[OH-].[Li+:26]>CO.O1CCCC1>[Li+:26].[C:16]([O:15][C:13]([C:10]1[S:9][C:8]([CH2:7][N:5]([CH3:6])[C@H:4]([C:3]([O-:24])=[O:2])[CH2:20][CH:21]([CH3:23])[CH3:22])=[CH:12][CH:11]=1)=[O:14])([CH3:17])([CH3:18])[CH3:19]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 90107000N-[(5-tert-butoxycarbonylthiophen-2-yl)methyl]-N-methyl-L-leucine methyl ester

生成物 1

HCID 90107093N-[(5-tert-butoxycarbonylthiophen-2-yl)methyl]-N-methyl-L-leucine lithium salt

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

The compound (0.87 g, 2.4 mmol) obtained in step 1 was dissolved in methanol (2.7 mL) and tetrahydrofuran (5.4 mL), 1N aqueous lithium hydroxide solution (2.7 mL) was added, and the mixture was stirred overnight. The reaction mixture was concentrated under reduced pressure, water was added, and the mixture was lyophilized to give the title compound (0.83 g).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure, water
  2. additionwas added

出典と根拠

ORDレコード
ord-10db9cde73e744afab8004bee3ca1c64
出典データセット
uspto-grants-2016_05
特許番号
US09346821B2

反応ノート

読み込み中…