Trifluoroacetic acid → 5-Bromo-6-cyclopropyl-3-iodopyridin-2-amine

HRID 531445ノート

反応式

HRID 531445 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:11])=[N:6][C:7]=1[CH:8]1[CH2:10][CH2:9]1.FC(F)(F)C(O)=O.[I:19]N1C(=O)CCC1=O>>[Br:1][C:2]1[CH:3]=[C:4]([I:19])[C:5]([NH2:11])=[N:6][C:7]=1[CH:8]1[CH2:9][CH2:10]1

参加物

4

反応物 3

HCID 6422Trifluoroacetic acidHCID 120273N-IodosuccinimideHCID 900221395-Bromo-6-cyclopropylpyridin-2-amine

生成物 1

HCID 900227685-Bromo-6-cyclopropyl-3-iodopyridin-2-amine収率 100%

実験手順

A solution of 5-bromo-6-cyclopropylpyridin-2-amine (2.1 g, 9.81 mmol), trifluoroaceticacid (170 mg, 1.47 mmol), N-iodosuccinimide (2.2 g, 9.81 mmol) stirred at room temperature for 30 minutes. Reaction mass was quenched with water, basified with ammonium hydroxide solution. Solid separated was filtered and dried to get 3.3 g (100% yield) of titled compound. 1H NMR (CDCl3, 300 MHz): δ 7.85 (s, 1H), 4.80-4.65 (bs, 2H), 2.39-2.25 (m, 1H), 1.0-0.90 (m, 4H). MS: m/z=338.9 (M+1).

後処理

  1. customReaction mass
  2. customwas quenched with water
  3. customSolid separated
  4. filtrationwas filtered
  5. customdried

出典と根拠

ORDレコード
ord-1964b8422f8c46aebd9ca5d09c80cde2
出典データセット
uspto-grants-2016_05
特許番号
US09353107B2

反応ノート

読み込み中…