Borane → 6-(2-hydroxyethyl)-3-methyloxazolo[4,5-b]pyridin-2(3H)-one

HRID 53166

反応式

HRID 53166 の反応式
B.CC(C(C)C)=C.[CH3:8][N:9]1[C:13]2=[N:14][CH:15]=[C:16]([CH:18]=[CH2:19])[CH:17]=[C:12]2[O:11][C:10]1=[O:20].C(B)(C(C)C)(C)C.[OH-:28].[Na+]>O1CCCC1.O>[OH:28][CH2:19][CH2:18][C:16]1[CH:17]=[C:12]2[O:11][C:10](=[O:20])[N:9]([CH3:8])[C:13]2=[N:14][CH:15]=1

参加物

8

反応物 5

HCID 6331BoraneHCID 112492,3-Dimethyl-1-buteneHCID 14798Sodium HydroxideHCID 5326179InChI=1/C6H15B/c1-5(2)6(3,4)7/h5H,7H2,1-4HHCID 190792863-methyl-6-vinyloxazolo[4,5-b]pyridin-2(3H)-one

生成物 1

HCID 190793176-(2-hydroxyethyl)-3-methyloxazolo[4,5-b]pyridin-2(3H)-one収率 78%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

A solution of boron hydride (1M in tetrahydrofuran) (5 ml, 5 mmol) is cooled using a salt/ice bath, and then 2,3-dimethyl-1-butene (0.6 ml, 5 mmol) are slowly added. The temperature of the solution is increased to 0° C. and stirring is maintained for a further 2 hours at that temperature. 3-methyl-6-vinyloxazolo[4,5-b]pyridin-2(3H)-one (1.14 mg, 5 mmol) dissolved in tetrahydrofuran (20 ml) is added to the previously prepared solution of thexylborane. The whole is stirred at 0° C. for 2 hours, then a 10% aqueous sodium hydroxide solution (2.40 ml) and also oxygenated water (2.00 ml) are added in succession. After 1 hour's stirring at room temperature and evaporation of the solvent under reduced pressure, the residue is taken up in water. Extraction is carried out with dichloromethane; the organic phase is dried over magnesium sulfate and filtered, and then the solvent is evaporated off under reduced pressure. Purification by flash chromatography on silica gel (eluant: dichloromethane/methanol: 95/5) yields 6-(2-hydroxyethyl)-3-methyloxazolo[4,5-b]pyridin-2(3H)-one in a yield of 78%.

後処理

  1. temperatureis maintained for a further 2 hours at that temperature
  2. stirringThe whole is stirred at 0° C. for 2 hours
  3. stirringAfter 1 hour's stirring at room temperature
  4. customevaporation of the solvent under reduced pressure
  5. extractionExtraction
  6. dry with materialthe organic phase is dried over magnesium sulfate
  7. filtrationfiltered
  8. customthe solvent is evaporated off under reduced pressure
  9. customPurification by flash chromatography on silica gel (eluant: dichloromethane/methanol: 95/5)

出典と根拠

ORDレコード
ord-e08226f300284e3098a50c89a9721865
出典データセット
uspto-grants-1997_04
特許番号
US05618819

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