Dimethylformamide → 7-bromo-4-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine
反応式
[Br:1][C:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10]([Cl:11])[C:5]=2[NH:4][CH:3]=1.[CH3:12]N(C)C=O.[H-].[Na+].CI>C(OCC)(=O)C>[Br:1][C:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10]([Cl:11])[C:5]=2[N:4]([CH3:12])[CH:3]=1参加物
6
反応条件
- 温度
- 50 °C
実験手順
To 7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine (147 mg), N,N-dimethylformamide (10 mL) was added, and NaH (36 mg) was further added thereto, followed by stirring for 30 min. Subsequently, methyl iodide was added thereto, and the reaction mixture was heated to 50° C. and stirred for 2 hours. After completion of the reaction, the reaction mixture was mixed with ethyl acetate and washed with water. The washed mixture was dried over anhydrous sodium sulfate, and filtered and distilled under reduced pressure to obtain the title compound.
後処理
- stirringstirred for 2 hours
- customAfter completion of the reaction
- washwashed with water
- dry with materialThe washed mixture was dried over anhydrous sodium sulfate
- filtrationfiltered
- distillationdistilled under reduced pressure
出典と根拠
- ORDレコード
- ord-f40f16950556459c9b68d8b64f2ae3b1
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08853213B2
反応ノート
読み込み中…