Water → (1R,2S)-(+)-cis-1-Amino-2-indanol

HRID 53297

反応式

HRID 53297 の反応式
[C@@H:1]1(O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@H:2]1[OH:10].S(=O)(=O)(O)O.O.[OH-].[Na+].C(#[N:22])C>>[NH2:22][C@@H:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C@@H:2]1[OH:10]

参加物

6

反応物 5

HCID 962WaterHCID 1118Sulfuric AcidHCID 6342Acetonitrile2 回HCID 14798Sodium HydroxideHCID 247603trans-1,2-Indandiol

生成物 1

HCID 2725045(1R,2S)-(+)-cis-1-Amino-2-indanol収率 63%

反応条件

温度
0 °C

実験手順

Trans-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C. , and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol (1.02 g, 63% yield).

後処理

  1. temperatureThe mixture was gradually warmed to 20° C. and aged to 3 hours
  2. temperaturethe mixture heated to reflux
  3. customThe resulting solid was removed by filtration

出典と根拠

ORDレコード
ord-7a5d12c0d0194441817fba2295d984dc
出典データセット
uspto-grants-1997_04
特許番号
US05618937

関連ノート

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