Water → HCID 67316267、化合物

HRID 533235

反応式

HRID 533235 の反応式
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][C:10]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19])(=O)=O.[C:23]1([SH:33])[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:26]=[CH:25][CH:24]=1.C(=O)([O-])[O-].[K+].[K+].O>C(#N)C>[C:23]1([S:33][CH2:6][CH2:7][CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]=2[C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:26]=[CH:25][CH:24]=1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 682591-NaphthalenethiolHCID 87353567HCID 87353567、化合物

生成物 1

HCID 67316267HCID 67316267、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of EXAMPLE 10A (42 mg), naphthalene thiol (45 mg), and potassium carbonate (36 mg) in acetonitrile (2 mL) was heated at 80° C. for 3 days. The reaction mixture was poured into water, extracted with dichloromethane and purified by flash chromatography on silica gel with 0-20% ethyl acetate in hexanes.

後処理

  1. extractionextracted with dichloromethane
  2. custompurified by flash chromatography on silica gel with 0-20% ethyl acetate in hexanes

出典と根拠

ORDレコード
ord-e1dfa09626a14fc0925b8340aa0a84fc
出典データセット
uspto-grants-2014_10
特許番号
US08853209B2

関連ノート

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