反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([C:20](O)=[O:21])[CH:18]=2)[N:13]=[CH:12][CH:11]=1.CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1.[N+]([O-])(O)=O.[CH3:49][C:50]1[CH:54]=[C:53]([CH3:55])[N:52]([C:56](=[NH:58])[NH2:57])[N:51]=1.CCN(C(C)C)C(C)C>O.CN(C=O)C>[NH2:58][C:56]([N:52]1[C:53]([CH3:55])=[CH:54][C:50]([CH3:49])=[N:51]1)=[N:57][C:20]([C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][CH:11]=[C:10]2[C:3]1[C:2]([F:1])=[CH:7][C:6]([F:8])=[CH:5][C:4]=1[F:9])=[O:21]参加物
8
反応物 5
生成物 1
試薬・触媒・溶媒 2
実験手順
A mixture of 4-(2,4,6-trifluorophenyl)quinoline-6-carboxylic acid (118 mg), WSC hydrochloride (112 mg), HOBt (37 mg), and DMF (4 mL) was stirred at room temperature for 5 minutes, and then 3,5-dimethyl-1H-pyrazole-1-carboximidamide nitrate (94 mg) and DIPEA (76 mg) were added thereto, followed by stirring for an additional 24 hours. The reaction mixture was diluted with water, and the precipitate was collected by filtration to obtain N-[1-amino(3,5-dimethyl-1H-pyrazol-1-yl)methylene]-4-(2,4,6-trifluorophenyl)quinoline-6-carboxamide (140 mg).
後処理
- stirringby stirring for an additional 24 hours
- filtrationthe precipitate was collected by filtration
出典と根拠
- ORDレコード
- ord-307778821b1a40cc925d19ba7f9edaed
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08853242B2
関連ノート
読み込み中…