Hydrochloric Acid → HCID 67776011、化合物
反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([C:20]([O:22]C)=[O:21])[CH:18]=2)[CH:13]=[CH:12][N:11]=1.[OH-].[Na+].C1COCC1.[ClH:31]>C(O)C>[ClH:31].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([C:20]([OH:22])=[O:21])[CH:18]=2)[CH:13]=[CH:12][N:11]=1参加物
6
実験手順
A mixture of methyl 1-(2,4,6-trifluorophenyl)isoquinoline-7-carboxylate (228 mg), a 1M aqueous sodium hydroxide solution (4 mL), THF (3 mL), and ethanol (3 mL) was stirred at room temperature for 24 hours. The reaction mixture was neutralized with 1M hydrochloric acid, and the precipitate was collected by filtration to obtain 1-(2,4,6-trifluorophenyl)isoquinoline-7-carboxylic acid hydrochloride (200 mg).