Dimethyl Sulfoxide → 6-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-ol

HRID 533925

反応式

HRID 533925 の反応式
CS(C)=O.[OH:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]([OH:14])=O)=[N:10][CH:11]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.O[NH:28][C:29](=[NH:33])[CH:30]([CH3:32])[CH3:31]>CC(=O)OCC>[CH:30]([C:29]1[N:33]=[C:12]([C:9]2[N:10]=[CH:11][C:6]([OH:5])=[CH:7][CH:8]=2)[O:14][N:28]=1)([CH3:32])[CH3:31]

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 682631,1'-CarbonyldiimidazoleHCID 2687405-Hydroxypyridine-2-carboxylic acidHCID 178449908HCID 178449908、化合物

生成物 1

HCID 1363773006-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-ol

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
90 °C

実験手順

To DMSO (25 mL) was added 5-hydroxy-pyridine-2-carboxylic acid (1.0 g) and CDI (1.3 g). After 15 minutes N-hydroxy-isobutyramidine (820 mg) was added. After 1 hour the mixture was heated to 90° C. for 1 hour. After the mixture reached room temperature, it was diluted with EA and washed three times with HCl (0.1 M). The organic phase was dried (Na2SO4) and concentrated to provide the title compound. MS ESI+: m/z=206 [M+H]+.

後処理

  1. customreached room temperature
  2. washwashed three times with HCl (0.1 M)
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-989f920584734f61b7577085f4131722
出典データセット
uspto-grants-2014_10
特許番号
US08853412B2

関連ノート

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