N-bromobutanimide → 5-Bromo-4-chloro-6-(2-phenylethynyl)pyridin-2-amine
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:5]=[C:4]([NH2:16])[CH:3]=1.C1C(=O)N([Br:24])C(=O)C1>C(#N)C>[Br:24][C:7]1[C:2]([Cl:1])=[CH:3][C:4]([NH2:16])=[N:5][C:6]=1[C:8]#[C:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1参加物
4
実験手順
A mixture of 4-chloro-6-(2-phenylethynyl)pyridin-2-amine B3a (1.0 g, 4.37 mmol), NBS (778 mg, 4.37 mmol) and ACN (20 ml) is stirred for 3 h at RT in the dark. The mixture is concentrated in vacuo and the product purified NP chromatography. Yield: 1.0 g (74%). HPLC-MS: M+H=307/309.
後処理
- concentrationThe mixture is concentrated in vacuo
- customthe product purified NP chromatography
出典と根拠
- ORDレコード
- ord-353c3fa3196042598fd525898b4361c0
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08859541B2
反応ノート
読み込み中…