Thionyl Chloride → 4-(Chloromethyl)-3-fluoropyridine hydrochloride

HRID 536485ノート

反応式

HRID 536485 の反応式
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8]O.S(Cl)([Cl:12])=O>C(#N)C>[ClH:12].[Cl:12][CH2:8][C:7]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[F:1]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 49760376(3-Fluoropyridin-4-yl)methanol

生成物 1

HCID 713062034-(Chloromethyl)-3-fluoropyridine hydrochloride

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

反応条件

温度
50 °C

実験手順

6.710 g (52.785 mmol) of (3-fluoropyridin-4-yl)methanol was put in 29 ml acetonitrile and heated to 50° C. Then a solution of 7.701 ml thionyl chloride in 14.5 ml acetonitrile was added dropwise and the reaction mixture was stirred for 4 h at 50° C. Then the reaction mixture was concentrated by evaporation and was co-distilled three times with dichloromethane. After drying under high vacuum, 10.27 g of the title compound was obtained, which was used in the next step without further purification.

後処理

  1. concentrationThen the reaction mixture was concentrated by evaporation
  2. customAfter drying under high vacuum

出典と根拠

ORDレコード
ord-53cd80e5e96045c68d55a431d243c5a9
出典データセット
uspto-grants-2014_10
特許番号
US08859569B2

反応ノート

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