Sodium Carbonate → Ethyl 5-bromofuran-3-carboxylate

HRID 537060

反応式

HRID 537060 の反応式
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:2]1.[Br:11]Br.C([O-])([O-])=O.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:11][C:5]1[O:1][CH:2]=[C:3]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH:4]=1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 24408BromineHCID 69201Ethyl 3-furoate

生成物 1

HCID 14592142Ethyl 5-bromofuran-3-carboxylate収率 53.3%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a solution of ethyl 3-furoate (50.0 g, 360 mmol) in chloroform (380 mL) was added bromine (56.0 g, 360 mmol) in chloroform. The reaction mixture was allowed to stir at rt overnight and then poured into 10% aqueous Na2CO3. The mixture was extracted with DCM. The organic solutions were combined and washed with water until pH=7. The organic solution was concentrated and then distilled to give ethyl 5-bromo-3-furoate (42 g, 40%).

後処理

  1. extractionThe mixture was extracted with DCM
  2. washwashed with water until pH=7
  3. concentrationThe organic solution was concentrated
  4. distillationdistilled

出典と根拠

ORDレコード
ord-7406ec14cb494712806516432f970ee3
出典データセット
uspto-grants-2014_10
特許番号
US08859768B2

関連ノート

読み込み中…