Sodium Iodide → 1-Iodoethyl isopropyl carbonate
反応式
[I-:1].[Na+].[C:3](=[O:12])([O:8][CH:9]([CH3:11])[CH3:10])[O:4][CH2:5][CH2:6]Cl>C(#N)C>[C:3](=[O:12])([O:8][CH:9]([CH3:11])[CH3:10])[O:4][CH:5]([I:1])[CH3:6]参加物
4
反応条件
- 温度
- 60 °C
実験手順
Sodium iodide (20.69 g, 138.0 mmol) was added to the crude solution of chloroethyl isopropyl carbonate (5.11 g, 30.67 mmol) in acetonitrile (50 mL). The resulting mixture was heated to 60° C. for 2 hours and then allowed to cool to 25° C. The reaction mixture was concentrated under reduced pressure and the resulting mixture was treated with diethyl ether. The solids were filtered off and the filtrate was concentrated under reduced pressure to obtain 1-iodoethyl isopropyl carbonate as a dark orange oil (5.43 g, 69% yield).
後処理
- temperatureto cool to 25° C
- concentrationThe reaction mixture was concentrated under reduced pressure
- additionthe resulting mixture was treated with diethyl ether
- filtrationThe solids were filtered off
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-38d3a8e5f0a74ecd9e034c3416016ffb
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08859781B2
反応ノート
読み込み中…