Water → 4-Amino-5-chloro-2-(2-propenyloxy)benzoic acid

HRID 5375

反応式

HRID 5375 の反応式
[H-].[Na+].C[O:4][C:5](=[O:15])[C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([NH2:13])=[CH:8][C:7]=1[OH:14].[CH2:16](Br)[CH:17]=[CH2:18].O>CN(C)C=O>[NH2:13][C:9]1[C:10]([Cl:12])=[CH:11][C:6]([C:5]([OH:4])=[O:15])=[C:7]([O:14][CH2:18][CH:17]=[CH2:16])[CH:8]=1

参加物

6

反応物 4

HCID 962WaterHCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 14883223Methyl 4-amino-5-chloro-2-hydroxybenzoate

生成物 1

HCID 117463644-Amino-5-chloro-2-(2-propenyloxy)benzoic acid収率 62.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A suspension of 60% sodium hydride/oil dispersion (1.52 g, 38 mmol) in anhydrous dimethylformamide (50 mL) under nitrogen was treated in portions with 4-amino-5-chloro-2-hydroxybenzoic acid methyl ester (6.05 g, 30 mmol), stirred at room temperature for 30 minutes, and treated with allyl bromide (4.60 g, 38 mmol). The mixture was stirred at 95°±5° C. for one hour, cooled to room temperature, and added to water (250 mL). The solid was removed by filtration and saved, and the filtrate was extracted with ether (2×100 mL). The concentrated ethereal extracts were combined with the filtered solid, taken up in 20% aqueous ethanol (100 mL), treated with potassium hydroxide (10 g), and refluxed for 45 minutes. The ethanol was removed in vacuo and the aqueous solution was extracted with ether (50 mL) and petroleum ethers (30°-60°, 50 mL), cooled (0° C.), and acidified to pH 4 with concentrated hydrochloric acid (17 mL). The suspension was filtered and the solid was air dried, dissolved in methylene chloride (150 mL) containing a little methanol, dried (Na2SO4), and concentrated in vacuo. Trituration from cold ether/petroleum ethers (30°-60°) and recrystallization from ethyl acetate/hexane (2 crops) afforded 4.25 g (62.2%) of a pale tan solid; mp 136°-137° C.

後処理

  1. stirringThe mixture was stirred at 95°±5° C. for one hour
  2. temperaturecooled to room temperature
  3. customThe solid was removed by filtration
  4. extractionthe filtrate was extracted with ether (2×100 mL)
  5. additiontreated with potassium hydroxide (10 g)
  6. temperaturerefluxed for 45 minutes
  7. customThe ethanol was removed in vacuo
  8. extractionthe aqueous solution was extracted with ether (50 mL) and petroleum ethers (30°-60°, 50 mL)
  9. temperaturecooled (0° C.)
  10. filtrationThe suspension was filtered
  11. customdried
  12. dissolutiondissolved in methylene chloride (150 mL)
  13. additioncontaining a little methanol
  14. dry with materialdried (Na2SO4)
  15. concentrationconcentrated in vacuo
  16. customTrituration from cold ether/petroleum ethers (30°-60°) and recrystallization from ethyl acetate/hexane (2 crops)

出典と根拠

ORDレコード
ord-257d8a8cf6e94ad4a79fa20e809fe6eb
出典データセット
uspto-grants-1993_09
特許番号
US05244907

関連ノート

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