Ethanol → 2-methyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenol

HRID 537562ノート

反応式

HRID 537562 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[N:16]2)=[CH:11][C:10]=1[CH3:24])C1C=CC=CC=1.C(O)C.[H][H]>[OH-].[OH-].[Pd+2].C1COCC1>[CH3:24][C:10]1[CH:11]=[C:12]([N:15]2[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[N:16]2)[CH:13]=[CH:14][C:9]=1[OH:8]

参加物

6

反応物 3

HCID 702EthanolHCID 681565621-(4-(benzyloxy)-3-methylphenyl)-4-(trifluoromethyl)-1H-pyrazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 681562662-methyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenol収率 86.7%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 1-(4-(benzyloxy)-3-methylphenyl)-4-(trifluoromethyl)-1H-pyrazole (670 mg, 2.0 mmol), 20% palladium hydroxide on activated carbon (50 mg), ethanol (20 ml), and THF (20 ml) was shaken under 40 psi of hydrogen gas at the ambient temperature for 3 days and at +50° for 1 day, to drive reaction to completion. The reaction was filtered through a pad of Celite and the mother liquor was concentrated to obtain the target product as a colorless solid (420 mg, 86%). MS (M+1): 243.0.

後処理

  1. customreaction to completion
  2. filtrationThe reaction was filtered through a pad of Celite
  3. concentrationthe mother liquor was concentrated

出典と根拠

ORDレコード
ord-cee29c5d5b734b6d84651e2ac1fc04c5
出典データセット
uspto-grants-2014_10
特許番号
US08859591B2

反応ノート

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