Lithium Hydroxide → 7-chloro-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

HRID 538222ノート

反応式

HRID 538222 の反応式
[OH-:1].[Li+].[Cl:3][C:4]1[N:9]=[C:8](SC)[N:7]2[CH:12]=[C:13]([CH2:15][O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=[C:6]2[CH:5]=1>O.C1COCC1.C(Cl)Cl>[Cl:3][C:4]1[NH:9][C:8](=[O:1])[N:7]2[CH:12]=[C:13]([CH2:15][O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=[C:6]2[CH:5]=1

参加物

6

反応物 2

HCID 3939Lithium HydroxideHCID 866964987-Chloro-5-methylsulfanyl-2-phenoxymethyl-imidazo[1,2-c]pyrimidine

生成物 1

HCID 1363786247-chloro-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one収率 98.2%

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

A solution of lithium hydroxide (66 mg, 2.75 mmol) in H2O (10 mL) was added to a solution of 7-chloro-5-methylsulfanyl-2-phenoxymethyl-imidazo[1,2-c]pyrimidine (0.70 g, 2.29 mmol) in THF (10 mL). The mixture was stirred at 50° C. for 4 hours and then diluted with DCM. The organic layer was separated, dried (Na2SO4), filtered and the solvents evaporated in vacuo to yield 7-chloro-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one (0.62 g, 98% yield) as a white solid that was used in the next step without further purification.

後処理

  1. customThe organic layer was separated
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. customthe solvents evaporated in vacuo

出典と根拠

ORDレコード
ord-8e0e01159a9e4dddb29aa7743b138b56
出典データセット
uspto-grants-2014_10
特許番号
US08865725B2

反応ノート

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