3-Hydroxybenzaldehyde → Ethyl 2-(3-formylphenoxy)acetate
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]>O1CCCC1>[CH:5]([C:4]1[CH:3]=[C:2]([CH:9]=[CH:8][CH:7]=1)[O:1][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=[O:6]参加物
5
実験手順
3-Hydroxybenzaldehyde (2.00 g, 16.4 mmol) was dissolved in 25 mL of dry tetrahydrofuran under nitrogen with 3.5 g of potassium carbonate and 3.01 g (18.0 mmol) of ethyl bromoacetate. The reaction was heated at reflux for 6 hr, then cooled to room temperature and filtered from inorganic salts. The filtrate was evaporated, redissolved in 30 mL of methylene chloride, washed with 2×15 mL of water, and dried over sodium sulfate. Evaporation of solvent gave 2.92 of ethyl 3-formylphenoxyacetate as a yellow oil.
後処理
- temperatureThe reaction was heated
- temperatureat reflux for 6 hr
- filtrationfiltered from inorganic salts
- customThe filtrate was evaporated
- dissolutionredissolved in 30 mL of methylene chloride
- washwashed with 2×15 mL of water
- dry with materialdried over sodium sulfate
- customEvaporation of solvent
出典と根拠
- ORDレコード
- ord-35fc4888bceb4e34b5c9ca3925a8439c
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08865721B2
反応ノート
読み込み中…