Triethylamine → AG-E-14754
反応式
Cl[C:2](Cl)([O:4][C:5](=[O:11])OC(Cl)(Cl)Cl)Cl.[NH2:13][C@@H:14]([CH2:17][CH2:18][CH3:19])CO.CCN(CC)CC>C1COCC1>[CH2:17]([C@H:14]1[CH2:2][O:4][C:5](=[O:11])[NH:13]1)[CH2:18][CH3:19]参加物
5
実験手順
A solution of triphosgene (0.431 g, 1.45 mmol) in THF (5 mL) was added dropwise to a stirred solution of (S)-2-aminopentan-1-ol (0.500 g, 4.85 mmol) and Et3N (1.49 mL, 10.7 mmol) in THF (22 mL) at 0° C. under N2. The reaction mixture was stirred at ambient temperature for 2 hours. After cooling, the suspension was filtered through GF/F paper and concentrated in vacuo. The residue was taken up in EtOAc and washed with 10% HCl, dried and concentrated to give (S)-4-propyloxazolidin-2-one (0.348 g, 55%) as a clear oil.
後処理
- temperatureAfter cooling
- filtrationthe suspension was filtered through GF/F paper
- concentrationconcentrated in vacuo
- washwashed with 10% HCl
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-cbb784382e724a8da7cfa259d933cd2a
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08865726B2
反応ノート
読み込み中…