Ethyl bromoacetate → Ethyl 2-(2-acetyl-4-bromophenoxy)acetate

HRID 53949

反応式

HRID 53949 の反応式
[C:1]([C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[CH:6][C:5]=1[OH:11])(=[O:3])[CH3:2].Br[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.C(Cl)(Cl)Cl>[C:1]([C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[CH:6][C:5]=1[O:11][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])(=[O:3])[CH3:2]

参加物

6

反応物 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 959915'-Bromo-2'-hydroxyacetophenone

生成物 1

HCID 19261366Ethyl 2-(2-acetyl-4-bromophenoxy)acetate収率 90.2%

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 6212Chloroform溶媒

実験手順

13.31 g of 2-acetyl-4-bromophenol, 11.0 g of ethyl bromoacetate and 9.7 g of anhydrous potassium carbonate were refluxed under heating in 70 ml of acetone for 2 hours. Insoluble materials were removed by filtration, and the resulting filtrate was concentrated and dried. The residue thus obtained was dissolved in chloroform, washed with water, and then dried to remove the solvent. The thus treated residue was washed with a mixed solvent system of ethanol and n-hexane to isolate insoluble crystals by filtration. In this way, 16.82 g of ethyl (2-acetyl-4-bromophenyl)oxyacetate was obtained in the form of colorless plate crystals.

後処理

  1. customInsoluble materials were removed by filtration
  2. concentrationthe resulting filtrate was concentrated
  3. customdried
  4. customThe residue thus obtained
  5. washwashed with water
  6. customdried
  7. customto remove the solvent
  8. washThe thus treated residue was washed with a mixed solvent system of ethanol and n-hexane
  9. customto isolate insoluble crystals
  10. filtrationby filtration

出典と根拠

ORDレコード
ord-2031b461fb474e2485dbe138cd102dc3
出典データセット
uspto-grants-1997_04
特許番号
US05620991

関連ノート

読み込み中…