Methyl iodide → 3-(4-fluoro-phenyl)-5-methylsulfanyl-3,6-dihydro-2H-[1,4]thiazine
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[NH:13][C:12](=[S:14])[CH2:11][S:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:15]I>C1COCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[N:13]=[C:12]([S:14][CH3:15])[CH2:11][S:10][CH2:9]2)=[CH:6][CH:7]=1参加物
4
実験手順
To a room temperature solution of 5-(4-fluoro-phenyl)-thiomorpholine-3-thione (710 mg, 3.2 mmol) in THF (20 mL) was added methyl iodide (1.1 mL, 16.7 mmol). The mixture was stirred at room temperature in the dark 18 hours, then concentrated under reduced pressure to give crude 3-(4-fluoro-phenyl)-5-methylsulfanyl-3,6-dihydro-2H-[1,4]thiazine as a hydroiodide salt, which was used directly in without further purification.
後処理
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-b894313817a44fa4b5f46975e3e491dc
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871760B2
反応ノート
読み込み中…