Methyl iodide → Methyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-1-methyl-2-indolyl)propionate

HRID 53983

反応式

HRID 53983 の反応式
C(O[N:6]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH:18]([CH2:23][C:24]3[NH:25][C:26]4[C:31]([CH:32]=3)=[CH:30][C:29]([C:33]#[N:34])=[CH:28][CH:27]=4)[C:19]([O:21][CH3:22])=[O:20])=[CH:14][CH:13]=2)[C:7]1=C=O)(C)(C)C.[H-].[Na+].[CH3:39]I.[C:41]1([CH3:47])[CH:46]=CC=C[CH:42]=1.[C:48]([O:51]CC)(=[O:50])C>CN(C)C=O>[C:41]([O:51][C:48]([N:6]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([CH:18]([CH2:23][C:24]3[N:25]([CH3:39])[C:26]4[C:31]([CH:32]=3)=[CH:30][C:29]([C:33]#[N:34])=[CH:28][CH:27]=4)[C:19]([O:21][CH3:22])=[O:20])=[CH:14][CH:13]=2)[CH2:7]1)=[O:50])([CH3:47])([CH3:46])[CH3:42]

参加物

6

反応物 4

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 21584019Toluene ethylacetateHCID 86750715methyl 2-[4-[((3S)-1-tert-butoxy-carbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-indolyl)propionate

生成物 1

HCID 57060150Methyl 2-[4-[((3S)-1-tert-butoxycarbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-1-methyl-2-indolyl)propionate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

3.0 g of methyl 2-[4-[((3S)-1-tert-butoxy-carbonyl-3-pyrrolidinyl)oxy]phenyl]-3-(5-cyano-2-indolyl)propionate was dissolved in 30 ml of N,N-dimethylformamide, and then stirred under ice cooling. 270 mg of 60% sodium hydride was added to the above solution, and the stirring was continued for 10 minutes. The resulting reaction solution was mixed with 0.4 ml of methyl iodide, and the mixture was stirred at room temperature for 1 hour. The thus treated reaction solution was diluted with a toluene/ethyl acetate mixture, and then washed with an aqueous solution of ammonium chloride. After drying the resulting organic layer to distill off the solvent, the residue thus obtained was purified by subjecting it to silica gel column chromatography using a dichloromethane/acetone mixture as an elution solvent. In this way, 2.0 g of the title compound was obtained in a viscous and oily form.

後処理

  1. customThe resulting reaction solution
  2. stirringthe mixture was stirred at room temperature for 1 hour
  3. customThe thus treated reaction solution
  4. washwashed with an aqueous solution of ammonium chloride
  5. customAfter drying the resulting organic layer
  6. distillationto distill off the solvent
  7. customthe residue thus obtained
  8. customwas purified

出典と根拠

ORDレコード
ord-731ec348e485467bab9ae478512c5c5b
出典データセット
uspto-grants-1997_04
特許番号
US05620991

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