Hydrazine hydrate (1:1) → (2R)-oxolane-2-carbohydrazide
反応式
[O:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[C:6]([OH:8])=O.CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)[N:28]=[N:27]C=2C=1.O.NN>ClCCl>[O:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[C:6]([NH:27][NH2:28])=[O:8]参加物
6
反応条件
- 温度
- 25 °C
実験手順
To a round-bottom flask was added a solution of (R)-tetrahydrofuran-2-carboxylic acid (3.00 g, 25.8 mmol, 1.00 equiv) in dichloromethane (60 mL). EDC.HCl (7.37 g, 38.5 mmol, 1.50 equiv), HOBt (5.24 g, 38.8 mmol, 1.50 equiv), and hydrazine hydrate (2.60 g, 51.9 mmol, 2.00 equiv) were added to the reaction. The resulting solution was stirred overnight at 25° C. The solids were removed with filtration. The filtrate was concentrated in vacuo to yield 2.00 g (59%) of (R)-tetrahydrofuran-2-carbohydrazide as a yellow oil.
後処理
- customThe solids were removed with filtration
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-3bff4fe272fe451c990ef9e6a97ec23a
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08871790B2
反応ノート
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