Bromoacetic Acid → HCID 57962294、化合物

HRID 541730

反応式

HRID 541730 の反応式
Br[CH2:2][C:3]([OH:5])=O.[ClH:6].[F:7][C:8]([F:19])([F:18])[C:9]1[N:13]2[CH2:14][CH2:15][NH:16][CH2:17][C:12]2=[N:11][N:10]=1.Cl.CN(C)CCCN=C=NCC.C(N(CC)C(C)C)(C)C>ClCCl>[Cl:6][CH2:2][C:3]([N:16]1[CH2:15][CH2:14][N:13]2[C:9]([C:8]([F:18])([F:7])[F:19])=[N:10][N:11]=[C:12]2[CH2:17]1)=[O:5]

参加物

6

反応物 4

HCID 6227Bromoacetic AcidHCID 81531DiisopropylethylamineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 119613713-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

生成物 1

HCID 57962294HCID 57962294、化合物収率 33%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Bromoacetic acid (300 mg, 2.2 mmol) and 3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (490 mg, 2.2 mmol) were stirred in dichloromethane (5 mL) with N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (412 mg, 2.2 mmol) and N,N-diisopropylethylamine (560 mL, 3.2 μmol) for 3 hours at rt. The mixture was washed with water, dried over sodium sulfate and evaporated to give the desired compound in 33% yield. LCMS for C8H8ClF3N4O (M+H)+: m/z=269.0.

後処理

  1. washThe mixture was washed with water
  2. dry with materialdried over sodium sulfate
  3. customevaporated

出典と根拠

ORDレコード
ord-436f68b65c2443939f419eab38d75050
出典データセット
uspto-grants-2014_10
特許番号
US08871753B2

関連ノート

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