Diethyl Ether → Ethyl (6-methoxy-1h-indol-3-yl)(oxo)acetate

反応式

[C:1](Cl)(=[O:5])[C:2](Cl)=[O:3].[CH3:7][O:8][C:9]1[CH:17]=[C:16]2[C:12]([CH:13]=[CH:14][NH:15]2)=[CH:11][CH:10]=1.[CH2:18]([O:20]CC)[CH3:19]>>[CH3:7][O:8][C:9]1[CH:17]=[C:16]2[C:12]([C:13]([C:1](=[O:5])[C:2]([O:20][CH2:18][CH3:19])=[O:3])=[CH:14][NH:15]2)=[CH:11][CH:10]=1

参加物

反応物 3

HCID 3283Diethyl Ether

HCID 65578Oxalyl chloride

HCID 766596-Methoxy-1H-indole

生成物 1

HCID 19958885Ethyl (6-methoxy-1h-indol-3-yl)(oxo)acetate

実験手順

7.5 cm3 of oxalyl chloride are added dropwise, under argon and over a period of 30 minutes, to a solution of 8.3 g of 6-methoxyindole, prepared in accordance with the process described by P. L. Feldman and H. Rapoport, Synthesis, (1986), 736, in 100 cm3 of anhydrous diethyl ether. After stirring for two hours, the precipitate formed is separated by filtration and then suspended in 200 cm3 of ethanol.