Chloroform → N,N-dibenzyl-1-(oxiran-2-yl)methanamine

HRID 542785

反応式

HRID 542785 の反応式
Cl[CH2:2][CH:3]([OH:20])[CH2:4][N:5]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[OH-].[Na+].C(Cl)(Cl)Cl>O>[CH2:6]([N:5]([CH2:4][CH:3]1[CH2:2][O:20]1)[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

5

反応物 3

HCID 6212ChloroformHCID 14798Sodium HydroxideHCID 135354791-Chloro-3-dibenzylamino-2-propanol

生成物 1

HCID 11276836N,N-dibenzyl-1-(oxiran-2-yl)methanamine収率 76%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

50.7 g (0.175 mol) of 1-chloro-3-dibenzylamino-2-propanol and 9.5 g (0.24 mol) of sodium hydroxide in 5 ml of water are stirred together for one hour at 95° c. After the addition of 50 ml of chloroform and 20 ml of water, the phases are separated and the organic phase is washed with 20 ml of water, dehydrated with sodium sulphate and concentrated by evaporation. Distillation of the resulting yellow oil under vacuum yields 33.7 g (76%) of the oxirane as a colourless oil.

後処理

  1. customthe phases are separated
  2. washthe organic phase is washed with 20 ml of water
  3. concentrationconcentrated by evaporation
  4. distillationDistillation of the resulting yellow oil under vacuum

出典と根拠

ORDレコード
ord-77df8396dc084fb0a0092ea8b7aa3c41
出典データセット
uspto-grants-1987_04
特許番号
US04659721

関連ノート

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