Water → 2-(2-Iodo-5-methoxyphenyl)acetic acid

HRID 543425

反応式

HRID 543425 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[I:13]Cl.O>C(O)(=O)C.II>[I:13][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=1[CH2:9][C:10]([OH:12])=[O:11]

参加物

6

反応物 3

HCID 962WaterHCID 15719(3-Methoxyphenyl)acetic acidHCID 24640Iodine chloride

生成物 1

HCID 8200712-(2-Iodo-5-methoxyphenyl)acetic acid収率 65%

試薬・触媒・溶媒 2

HCID 807Iodine触媒HCID 176Acetic Acid溶媒

実験手順

A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).

後処理

  1. customthe solid collected
  2. customIt was recrystallized from toluene

出典と根拠

ORDレコード
ord-b4f7f8a97a8e42fb9576438e9b94f03a
出典データセット
uspto-grants-1987_04
特許番号
US04661635

関連ノート

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