反応式
CC(O[CH2:5][C:6]1[CH2:15][S:14][C@@H:9]2[C@H:10]([NH2:13])[C:11](=[O:12])[N:8]2[C:7]=1[C:16]([OH:18])=[O:17])=O.[SH:19][C:20]1[S:24][C:23]([S:25][CH2:26][C:27]([N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[O:28])=[N:22][N:21]=1.COC(C1C(Cl)=C(Cl)C(C(OC)=O)=C(Cl)C=1Cl)=O>C(#N)C>[NH2:13][CH:10]1[C:11](=[O:12])[N:8]2[C:7]([C:16]([OH:18])=[O:17])=[C:6]([CH2:5][S:19][C:20]3[S:24][C:23]([S:25][CH2:26][C:27]([N:29]4[CH2:30][CH2:31][O:32][CH2:33][CH2:34]4)=[O:28])=[N:22][N:21]=3)[CH2:15][S:14][C@H:9]12参加物
5
実験手順
While utilizing 0.680 g of 7-ACA, 0.900 g of 5-mercapto-2-morpholinocarbonylmethylthio-1,3,4-thiadiazole, 4.0 ml of acetonitrile and 2.70 g of DCPA, the procedure was carried out in accordance with Example 5, and there was obtained 1.02 g (83.3% of yield) of red brown powder of 7-amino-3-[(2-morpholinocarbonylmethylthio-1,3,4-thiadiazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid.
後処理
- customthere was obtained
出典と根拠
- ORDレコード
- ord-291c79c7964c4fc395677d94a85f454b
- 出典データセット
- uspto-grants-1984_05
- 特許番号
- US04446318
関連ノート
読み込み中…