Phthalic Anhydride → 5-[2-[2-(Carboxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine

HRID 5444

反応式

HRID 5444 の反応式
[NH2:1][CH2:2][CH2:3][S:4][C:5]1[N:10]2[CH:11]=[CH:12][N:13]=[C:9]2[CH:8]=[CH:7][CH:6]=1.[C:14]1(=[O:24])[O:19][C:17](=[O:18])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12>C(Cl)(Cl)Cl>[C:17]([C:16]1[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=1[C:14]([NH:1][CH2:2][CH2:3][S:4][C:5]1[N:10]2[CH:11]=[CH:12][N:13]=[C:9]2[CH:8]=[CH:7][CH:6]=1)=[O:24])([OH:19])=[O:18]

参加物

4

反応物 2

HCID 6811Phthalic AnhydrideHCID 152293695-[2-(Amino)ethylthio]imidazo[1,2-a]pyridine

生成物 1

HCID 233628395-[2-[2-(Carboxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine収率 84.8%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.12 g, 5.8 mmoles) in chloroform (58 ml) was added phthalic anhydride (1.12 g, 7.56 mmoles) and the mixture was stirred at room temperature for 14 hours and then heated at reflux for 5 hours. The reaction mixture was cooled by standing. The crystals precipitated were filtered off, washed with chloroform and dried to obtain 1.68 g of the desired product (84.8%, colorless crystals).

後処理

  1. temperatureheated
  2. temperatureat reflux for 5 hours
  3. temperatureThe reaction mixture was cooled
  4. customThe crystals precipitated
  5. filtrationwere filtered off
  6. washwashed with chloroform
  7. customdried

出典と根拠

ORDレコード
ord-201221c47b48468e8dcff804deda74d1
出典データセット
uspto-grants-1993_09
特許番号
US05244908

関連ノート

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