反応式
[C:1]([OH:21])(=[O:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18]=[CH2:19].C1(BC2CCCCC2)CCCCC1.C([O-])(=O)C.[Na+].[I-:40].[Na+].CC1C=CC(S(NCl)(=O)=O)=CC=1>>[I:40][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:1]([OH:21])=[O:20]参加物
6
実験手順
18-Nonadecenoic acid (100 mg, 0.34 mmol) was hydroborated with dicylohexylborane (0.7 mmol) at 0° C. The organoborane was iodinated with sodium aceate (0.7 mmol), sodium iodide (0.35 mmol), and chloramine-T (0.7 mmol). The product was isolated by column chromotography on silica gel (10% ethyl acetate:hexane):yield 129 mg (89%); m/e=424.5 (calcd 424.5); NMR (CDCl3) 1.2 δ (s, 30H, alkane), 2.1 (m, 4H, --CH2CO2H--CH2I), 3.0 (t, 2H, --CH2I), 11.9 (s, 1H, --CO2H).
後処理
- customThe product was isolated by column chromotography on silica gel (10% ethyl acetate:hexane)
出典と根拠
- ORDレコード
- ord-7f437dc3c7ac458a9838b3370473fb23
- 出典データセット
- uspto-grants-1984_05
- 特許番号
- US04450149
関連ノート
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