Ammonia → 1-Phenylimidazole

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:8].[CH:9]([CH:11]=O)=O.[CH2:13]=O>C(O)CC>[C:2]1([N:1]2[CH:11]=[CH:9][N:8]=[CH:13]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

実験手順

A mixture of 93.1 parts of aniline and 68 parts of 25% strength aqueous ammonia in 100 parts of propanol, and a mixture of 145 parts of 40% strength aqueous glyoxal solution and 75 parts of 40% strength aqueous formaldehyde solution are simultaneously stirred into 200 parts of propanol in the course of 30 minutes, at 80° C. The mixture is thenkept at 80° C. for a further 30 minutes. Thereafter the solvent is stripped off under reduced pressure and the residue is subjected to fractional distillation. 100.9 parts of N-phenylimidazole (boiling point 128° C./2 mm Hg) are obtained, corresponding to a yield of 70.0%.