Phenyl Isothiocyanate → 1-(4-Hydroxybutyl)-3-(3-phenylthioureido)pyrazole
反応式
[NH2:1][C:2]1[CH:6]=[CH:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][OH:11])[N:3]=1.[C:12]1([N:18]=[C:19]=[S:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(#N)C>[OH:11][CH2:10][CH2:9][CH2:8][CH2:7][N:4]1[CH:5]=[CH:6][C:2]([NH:1][C:19]([NH:18][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[S:20])=[N:3]1参加物
4
実験手順
To a solution of 3-amino-1-(4-hydroxybutyl)pyrazole (1.0 g.) in dry acetonitrile (3 ml.) was slowly added phenylisothiocyanate (0.95 g.) and the mixture was stirred at room temperature for 17 hours. The solvent was evaporated and the residue purified by column chromatography on silica gel using EtOAc as eluant to give 1-(4-hydroxybutyl)-3-(3-phenylthioureido)pyrazole (0.54 g.; 29%), m.p. 112°-117°.
後処理
- customThe solvent was evaporated
- customthe residue purified by column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-bb1c2e5ff6a449c18db79a5c178c6732
- 出典データセット
- uspto-grants-1984_05
- 特許番号
- US04451463
反応ノート
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