4-Methyl-3-nitroanisole → 5-Methoxy-o-toluidine
反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[N+:10]([O-])=O>CO.[Pd]>[NH2:10][C:3]1[CH:4]=[C:5]([O:8][CH3:9])[CH:6]=[CH:7][C:2]=1[CH3:1]参加物
4
実験手順
12.4 g of palladium-on-carbon are added to a solution of 132.9 g (0.759 mole) of 4-methyl-3-nitro-anisole in 1.1 liters of methanol and hydrogenation is carried out at room temperature. The catalyst is filtered off and the filtrate is concentrated in a vacuum rotary evaporator. Recrystallisation from isopropanol/water yields 3-amino-4-methylanisole having a melting point of 43°-44°.
後処理
- customis carried out at room temperature
- filtrationThe catalyst is filtered off
- concentrationthe filtrate is concentrated in a vacuum rotary evaporator
- customRecrystallisation from isopropanol/water
出典と根拠
- ORDレコード
- ord-6c3bae7188a248158e890e52b408fc42
- 出典データセット
- uspto-grants-1984_05
- 特許番号
- US04451462
反応ノート
読み込み中…