1-(5-Bromo-3-(trifluoromethyl)pyridin-2-yl)ethanol → 1-(5-Bromo-3-(trifluoromethyl)pyridin-2-yl)ethanone
反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:11]([F:14])([F:13])[F:12])[C:5]([CH:8]([OH:10])[CH3:9])=[N:6][CH:7]=1>C1COCC1.O=[Mn]=O>[Br:1][C:2]1[CH:3]=[C:4]([C:11]([F:14])([F:12])[F:13])[C:5]([C:8](=[O:10])[CH3:9])=[N:6][CH:7]=1参加物
4
実験手順
Dissolve 1-(5-bromo-3-(trifluoromethyl)pyridin-2-yl)ethanol (3.75 g, 0.01394 moles) in anhydrous THF (75 mL) and add MnO2 (12.1-24.2 g, 10 to 20 eq) at room temperature. Reflux the mixture under N2 atmosphere for 3 days. Cool the reaction mixture, filter through celite, wash the celite with THF (3×50 mL) and then concentrate under vacuum to afford the title compound as a colorless yellow oil.
後処理
- temperatureReflux the mixture under N2 atmosphere for 3 days
- temperatureCool the reaction mixture
- filtrationfilter through celite
- washwash the celite with THF (3×50 mL)
- concentrationconcentrate under vacuum
出典と根拠
- ORDレコード
- ord-036b11ee2e62428190f8be08d951fb6f
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07935702B2
反応ノート
読み込み中…