2-Nitrophenol → Benzyl 2-nitrophenyl ether
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([O-:3])=[O:2].[CH2:11](Br)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:11]([O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1参加物
5
実験手順
A stirred mixture of 2-nitrophenol (13.9 g, 0.10 mol), benzyl bromide (12.0 ml, 0.10 mol) and anhydrous potassium carbonate (30 g, 0.22 mol) in acetone (200 ml) is heated under reflux for 16 hours, cooled, poured onto ice-dilute hydrochloric acid, and extracted with dichloromethane. The extract is dried and evaporated and the residue is crystallized from ether-hexane as pale crystals, m.p. <50° C.
後処理
- temperatureis heated
- temperatureunder reflux for 16 hours
- temperaturecooled
- additionpoured onto ice-dilute hydrochloric acid
- extractionextracted with dichloromethane
- customThe extract is dried
- customevaporated
- customthe residue is crystallized from ether-hexane as pale crystals, m.p. <50° C.
出典と根拠
- ORDレコード
- ord-e44dbfde469446e78ff3839f598915a5
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05622969
反応ノート
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