2-Nitrophenol → Benzyl 2-nitrophenyl ether

HRID 54521

反応式

HRID 54521 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([O-:3])=[O:2].[CH2:11](Br)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:11]([O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 69472-NitrophenolHCID 7498Benzyl BromideHCID 11430Potassium Carbonate

生成物 1

HCID 736266Benzyl 2-nitrophenyl ether

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A stirred mixture of 2-nitrophenol (13.9 g, 0.10 mol), benzyl bromide (12.0 ml, 0.10 mol) and anhydrous potassium carbonate (30 g, 0.22 mol) in acetone (200 ml) is heated under reflux for 16 hours, cooled, poured onto ice-dilute hydrochloric acid, and extracted with dichloromethane. The extract is dried and evaporated and the residue is crystallized from ether-hexane as pale crystals, m.p. <50° C.

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 16 hours
  3. temperaturecooled
  4. additionpoured onto ice-dilute hydrochloric acid
  5. extractionextracted with dichloromethane
  6. customThe extract is dried
  7. customevaporated
  8. customthe residue is crystallized from ether-hexane as pale crystals, m.p. <50° C.

出典と根拠

ORDレコード
ord-e44dbfde469446e78ff3839f598915a5
出典データセット
uspto-grants-1997_04
特許番号
US05622969

関連ノート

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