Hydrochloric Acid → (4-Hydroxyphenoxy)acetic acid

HRID 546360

反応式

HRID 546360 の反応式
C[O:2][C:3](=[O:13])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.Cl>[OH-].[Na+]>[OH:12][C:9]1[CH:8]=[CH:7][C:6]([O:5][CH2:4][C:3]([OH:13])=[O:2])=[CH:11][CH:10]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 602731Methyl 2-(4-hydroxyphenoxy)acetate

生成物 1

HCID 15881(4-Hydroxyphenoxy)acetic acid

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

反応条件

温度
90 °C

実験手順

(4-Hydroxy-phenoxy)-acetic acid methyl ester 11 (20 grams, 109.89 mmol) is added to 10% sodium hydroxide solution (100 mL) and heated to 90° C. on water bath for 6 hours. The reaction mixture is cooled to room temperature, and the pH is adjusted to 2 with distilled HCl. Crude 12, is filtered, dried, and can be recrystallised in appropriate solvent.

後処理

  1. temperatureThe reaction mixture is cooled to room temperature
  2. filtrationCrude 12, is filtered
  3. customdried
  4. customcan be recrystallised in appropriate solvent

出典と根拠

ORDレコード
ord-9b60dbd7e8564d3083558297cd3660ca
出典データセット
uspto-grants-2011_05
特許番号
US07935843B2

関連ノート

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