Sodium Sulfite → 4-(4-Methoxycarbonylphenyl)pyridine N-oxide

HRID 546490ノート

反応式

HRID 546490 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][C:10]([C:11]([O:13][CH3:14])=[O:12])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.ClC1C=CC=C(C(OO)=[O:25])C=1.S([O-])([O-])=O.[Na+].[Na+]>ClCCl>[CH3:14][O:13][C:11]([C:10]1[CH:15]=[CH:16][C:7]([C:4]2[CH:5]=[CH:6][N+:1]([O-:25])=[CH:2][CH:3]=2)=[CH:8][CH:9]=1)=[O:12]

参加物

5

反応物 3

HCID 24437Sodium SulfiteHCID 70297m-Chloroperbenzoic acidHCID 5152686Methyl 4-(4-pyridinyl)benzoate

生成物 1

HCID 186176494-(4-Methoxycarbonylphenyl)pyridine N-oxide収率 83%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Methyl 4-(4-pyridyl)benzoate (1.49 g) was dissolved in dichloromethane (30 ml), 70% m-chloroperbenzoic acid (3.46 g) was added, and the mixture was stirred at room temperature for 1 hour. An aqueous solution of sodium sulfite was added to conduct liquid separation. The resultant organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and then dried over anhydrous sodium sulfate. The solvent was distilled off to obtain the title compound (1.33 g) as white powder.

後処理

  1. customliquid separation
  2. washThe resultant organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-b0c781d1b1954b4b9ce6ae30e8951e6e
出典データセット
uspto-grants-2011_05
特許番号
US07935824B2

反応ノート

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