Water → 4-(2-(Pyrrolidin-1-yl)ethyl)aniline

HRID 546644ノート

反応式

HRID 546644 の反応式
O=[C:2]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)[CH2:3][C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[N:11]1([CH2:2][CH2:3][C:4]2[CH:5]=[CH:6][C:7]([NH2:8])=[CH:9][CH:10]=2)[CH2:15][CH2:14][CH2:13][CH2:12]1

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 167707122-(4-Aminophenyl)-1-(pyrrolidin-1-yl)ethan-1-oneHCID 21226445Aluminium lithium hydride

生成物 1

HCID 64870474-(2-(Pyrrolidin-1-yl)ethyl)aniline収率 101.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 1.22 g of 4-(2-oxo-2-pyrrolidin-1-ylethyl)aniline obtained in stage b) below in 100 mL of tetrahydrofuran are added, under argon, 1.1 g of lithium aluminium hydride. The reaction mixture is stirred for one hour at room temperature and then cooled to 0° C. and treated successively with 1.1 mL of water, 1.1 mL of 15% (by weight) sodium hydroxide solution and 3.4 mL of water. The solid formed is filtered off and washed with ethyl acetate, and the filtrate is concentrated under reduced pressure to give 1.15 g of 4-(2-pyrrolidin-1-ylethyl)aniline, the characteristics of which are as follows:

後処理

  1. temperaturecooled to 0° C.
  2. customThe solid formed
  3. filtrationis filtered off
  4. washwashed with ethyl acetate
  5. concentrationthe filtrate is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-1a86a24f73e44cefbf9a903e7220bfe8
出典データセット
uspto-grants-2011_05
特許番号
US07935819B2

反応ノート

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