Acetone → L-Proline, 1-(1-methylethyl)- (9CI)
反応式
[NH:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[C:6]([OH:8])=[O:7].[CH3:9][C:10]([CH3:12])=O>CO.[Pd]>[CH:10]([N:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[C:6]([OH:8])=[O:7])([CH3:12])[CH3:9]参加物
5
実験手順
A suspension of (S)-pyrrolidine-2-carboxylic acid (5 g, 50 mmol), acetone (5.52 mL, 50 mmol) and 10% Pd/C (2.5 g) in methanol (100 mL) was stirred under hydrogen atmosphere for 6 to 12 hours. The reaction mixture was filtered on a pad of celite and the filtrate was concentrated. The residue obtained was filtered through a column of silica gel to afford (S)-1-isopropylpyrrolidine-2-carboxylic acid (8.0 g, 94%) as a colorless solid.
後処理
- filtrationThe reaction mixture was filtered on a pad of celite
- concentrationthe filtrate was concentrated
- customThe residue obtained
- filtrationwas filtered through a column of silica gel
出典と根拠
- ORDレコード
- ord-c7bcac0a3a7c493a88ae0a1727cc1612
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07939513B2
反応ノート
読み込み中…