Ammonia → 3-Nitro-1-phenyl-1,2-dihydropyridin-2-one

HRID 547678ノート

反応式

HRID 547678 の反応式
[OH:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[C:11]1(B(O)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(N(CC)CC)C.N>C([O-])(=O)C.[Cu+2].C([O-])(=O)C.O1CCCC1.N1C=CC=CC=1>[N+:8]([C:7]1[C:2](=[O:1])[N:3]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

参加物

8

反応物 4

HCID 222AmmoniaHCID 8471TriethylamineHCID 66827Phenylboronic AcidHCID 178526677HCID 178526677、化合物

生成物 1

HCID 223191573-Nitro-1-phenyl-1,2-dihydropyridin-2-one収率 61%

試薬・触媒・溶媒 3

HCID 8895Cupric acetate触媒HCID 1049Pyridine溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

5 g of 2-hydroxy-3-nitropyridine, 7.14 g of phenylboronic acid, 2.6 g of copper (II) acetate, 9.9 ml of triethylamine and 5.8 ml of pyridine were added to 100 ml of tetrahydrofuran, followed by stirring overnight. The reaction mixture was poured into aqueous ammonia, and extracted with ethyl acetate. The organic layer was washed with water, dried, and concentrated. The residue was suspended into ether, and collected by filtration, to give 4.71 g of the title compound.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated
  5. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-fb3ff16ca5aa47d8aaf202afc4195519
出典データセット
uspto-grants-2011_05
特許番号
US07939549B2

反応ノート

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