Ethylene Glycol → 2-(2-Bromo-5-fluorophenyl)-1,3-dioxolane

HRID 547785

反応式

HRID 547785 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[CH:4]=[O:5].[CH2:11](O)[CH2:12][OH:13]>C1(C)C=CC=CC=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>[Br:1][C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[CH:4]1[O:13][CH2:12][CH2:11][O:5]1

参加物

5

反応物 2

HCID 174Ethylene GlycolHCID 27733212-Bromo-5-fluorobenzaldehyde

生成物 1

HCID 671964552-(2-Bromo-5-fluorophenyl)-1,3-dioxolane収率 95%

試薬・触媒・溶媒 2

HCID 521998p-Toluenesulfonic acid monohydrate触媒HCID 1140Toluene溶媒

反応条件

温度
60 °C

実験手順

To a solution of 2.0 g (9.9 mmol) 2-bromo-5-fluorobenzaldehyde in 20 ml toluene were added 0.722 ml (13.0 mmol) ethane-1,2-diol and 5 mg (0.03 mmol) toluene-4-sulfonic acid monohydrate. The reaction mixture was heated in a rotary evaporator at 60° C. and 200 mbar during 4 h. After evaporation of the solvent and flash chromatography 2.32 g (95%) of the title compound were obtained as a colorless liquid.

後処理

  1. customAfter evaporation of the solvent

出典と根拠

ORDレコード
ord-e4fd57c228cc4e2f94cf88b7f8efc373
出典データセット
uspto-grants-2011_05
特許番号
US07939533B2

関連ノート

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