Isopropylamine → 2-Chloro-N-isopropyl-4-pyrimidinamine

HRID 548953ノート

反応式

HRID 548953 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([NH2:12])([CH3:11])[CH3:10].C(N(CC)CC)C>C(#N)C>[Cl:1][C:2]1[N:7]=[C:6]([NH:12][CH:9]([CH3:11])[CH3:10])[CH:5]=[CH:4][N:3]=1

参加物

5

反応物 3

HCID 6363IsopropylamineHCID 8471TriethylamineHCID 775312,4-Dichloropyrimidine

生成物 1

HCID 202849702-Chloro-N-isopropyl-4-pyrimidinamine

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

In analogy to compound 1.1, a solution of 0.347 g (2.33 mmol) of 2,4-dichloro-pyrimidine in 15 ml of acetonitrile is reacted with 0.22 ml (2.52 mmol) of isopropylamine in the presence of 0.39 ml (2.83 mmol) of triethylamine. Purification by chromatography (silica gel, ethyl acetate/hexane with ethyl acetate 0-100%) results in 0.26 g (65% of theory) of the product.

後処理

  1. customPurification by chromatography (silica gel, ethyl acetate/hexane with ethyl acetate 0-100%)
  2. customresults in 0.26 g (65% of theory) of the product

出典と根拠

ORDレコード
ord-195e515122f344739517d1768bca294f
出典データセット
uspto-grants-2011_05
特許番号
US07943629B2

反応ノート

読み込み中…