(2-Ethyl-pyrazolo[1,5-a]pyridin-3-yl)methanol → 2-Ethyl-pyrazolo[1,5-a]pyridine-3-carbaldehyde
反応式
[CH2:1]([C:3]1[C:11]([CH2:12][OH:13])=[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][N:5]2[N:4]=1)[CH3:2]>O1CCCC1.O=[Mn]=O>[CH2:1]([C:3]1[C:11]([CH:12]=[O:13])=[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][N:5]2[N:4]=1)[CH3:2]参加物
4
実験手順
To a solution of (2-ethyl-pyrazolo[1,5-a]pyridin-3-yl)-methanol (9.67 g, 54.9 mmol) in tetrahydrofuran (500 mL) was added MnO2 (23.88 g, 274.5 mmol, 85%, dried in oven at 120° C. for 16 h) and stirred at the reflux temperature for 1.5 h. The reaction mixture was filtered through a Celite pad, and concentrated under reduced pressure to give 9.4 g (98%) of product, which was used without further purification.
後処理
- filtrationThe reaction mixture was filtered through a Celite pad
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-b2f53e6e739644168ce9f7fb48a012be
- 出典データセット
- uspto-grants-2011_05
- 特許番号
- US07943652B2
反応ノート
読み込み中…