Ethanolamine → 6-Dimethylamino-4-(beta-hydroxyethylamino)quinoline

反応式

Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N:12]([CH3:14])[CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:15][CH2:16][CH2:17][OH:18].[OH-].[Na+]>O>[CH3:13][N:12]([CH3:14])[C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][CH:3]=[C:2]2[NH:15][CH2:16][CH2:17][OH:18]

参加物

実験手順

A mixture of 4-chloro-6-dimethylaminoquinoline 12 (4.92 g, 24 mmol), prepared according to the method described by Riegel et al., J. Am. Chem. Soc., 1946, 68, 1264, and of 2-aminoethanol (43.99 g, 720 mmol) is heated, with magnetic stirring, at 150° C. for 15 min and then at 185° C. for 30 min. After returning to ambient temperature, the solid is suspended in 25 ml of a 10%, w/v, aqueous sodium hydroxide solution and 165 ml of water. The precipitate obtained is filtered through sintered glass, washed with water and then dried under vacuum. The product is obtained in the form of a white powder: 4.86 g (yield=88%).