3-(Trifluoromethyl)phenol → 2-(3-Thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine

HRID 55121

反応式

HRID 55121 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.[H-].[Na+].Cl[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH2:22][C:23]2[CH:27]=[CH:26][S:25][CH:24]=2)[N:16]=1>CN(C)C=O.[Cu]I>[S:25]1[CH:26]=[CH:27][C:23]([CH2:22][O:21][C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([O:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=3)[N:16]=2)=[CH:24]1

参加物

6

反応物 3

HCID 73763-(Trifluoromethyl)phenolHCID 24758Sodium hydrideHCID 199574132-Chloro-6-(3-thienylmethyloxy)pyridine

生成物 1

HCID 199574052-(3-Thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine

試薬・触媒・溶媒 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution containing meta-trifluoromethylphenol (3.62 g, 0.0045×5.0 mol), sodium hydride (0.89 g, (Ca.60% in mineral oil), 0.0045×5.0 mol) and CuI (0.42 g, 0.0045×0.5 mol) in dimethylformamide, 2-chloro-6-(3-thienylmethyloxy)pyridine (1.0 g, 0.0045 mol) was added and the resultant solution was refluxed for about 3 hours.

後処理

  1. additionwas added

出典と根拠

ORDレコード
ord-6b619584c6cc4a48a4c6205325942da5
出典データセット
uspto-grants-1997_04
特許番号
US05624942

関連ノート

読み込み中…