Sodium hydride → 2-Chloro-4-methylamino-6-(3-thienylmethyloxy)pyridine

HRID 55133

反応式

HRID 55133 の反応式
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][OH:7])=[CH:2]1.[H-].[Na+].[Cl:10][C:11]1[CH:16]=[C:15]([NH:17][CH3:18])[CH:14]=[C:13](Cl)[N:12]=1>O1CCCC1>[Cl:10][C:11]1[CH:16]=[C:15]([NH:17][CH3:18])[CH:14]=[C:13]([O:7][CH2:6][C:3]2[CH:4]=[CH:5][S:1][CH:2]=2)[N:12]=1

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 123570Thiophene-3-methanolHCID 199573942,6-Dichloro-N-methylpyridin-4-amine

生成物 1

HCID 199574112-Chloro-4-methylamino-6-(3-thienylmethyloxy)pyridine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of 3-thiophenemethanol (1.42 g, 0.0113×1.1 mol) in 20 ml of dry tetrahydrofuran, sodium hydride (1.35 g (ca.60% in mineral oil), 0.0113×3.0 mol) was added. After the bubbling ceased, a solution of 2,6-dichloro-4-methylaminopyridine (2.0 g, 0.0113 mol) in 30 ml of dry tetrahydrofuran was added dropwise at room temperature.

出典と根拠

ORDレコード
ord-ed7deb2ac47349c198c996cbb3ace623
出典データセット
uspto-grants-1997_04
特許番号
US05624942

関連ノート

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